Analysis of the Metabolism of Dextran - Methylprednisolone Succinate Using In Vitro
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Synthesis and in vitro characterization of novel dextran-methylprednisolone conjugates with peptide linkers: effects of linker length on hydrolytic and enzymatic release of methylprednisolone and its peptidyl intermediates.
To control the rate of release of methylprednisolone (MP) in lysosomes, new dextran-MP conjugates with peptide linkers were synthesized and characterized. Methylprednisolone succinate (MPS) was attached to dextran 25 kDa using linkers with 1-5 Gly residues. The release characteristics of the conjugates in pH 4.0 and 7.4 buffers, blood, liver lysosomes, and various lysosomal proteinases were det...
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intravenous glucocorucoid pulse therapy is a common treatment for immunologically origin diseases but it can not be considered a completely bening treatment.the effects of long term administration of glucocorticoids on calcium and phosphorus metabolism are week known ,but is less in known about the effect of pluse therapy.the purpose of this study was to investigate the effect of methylpredn...
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In this prospective study the effect of low dose methylprednisolone succinate (10mg/kg) on the incidence of fat embolism syndrome and isolated arterial hypoxemia in 99 patients with long bone fracture (52 control and 47 steroid-trated subjects) was studied. Frequency of fractures among the selected patients was as follows: femoral fracture 52.5%, tibial fracture 36.4%, both femoral and tibial f...
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Fat embolism syndrome refers to a constellation of symptoms secondary to the presence of fat globules in the lung parenchyma and/or peripheral blood circulation. The syndrome is most often seen in association with long bone or pelvic fractures and can cause significant morbidity and mortality. The present randomized double blind placebo-controlled trial was conducted to evaluate the efficacy of...
متن کاملEffect of adrenocorticosteroid on glucose metabolism in BCG-sensitized alveolar macrophages.
The increases in oxidation of glucose-1-(14)C and glucose-6-(14)C in BCG-sensitized alveolar macrophages are inhibited by administration of methylprednisolone sodium succinate. Both resting and phagocytizing cells are affected.
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تاریخ انتشار 2005